Gold nanoparticle-based exonuclease III signal amplification for highly sensitive colorimetric detection of folate receptor.

نویسندگان

  • Xinjian Yang
  • Zhiqiang Gao
چکیده

By combining terminal protection of small molecule (folate)-capped DNA probes, exonuclease III signal amplification and gold nanoparticles, we developed a simple and label-free colorimetric assay for highly sensitive detection of folate receptor (FR). A detection limit of 50 fM FR was obtained using UV-vis spectrometry and 10 pM FR could be visualized by the naked eye.

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عنوان ژورنال:
  • Nanoscale

دوره 6 6  شماره 

صفحات  -

تاریخ انتشار 2014